FIELD: genetic engineering, biotechnology, medicine.
SUBSTANCE: invention relates to the prepared strain of Vibrio cholerae con comprising gene thyA in chromosome a resulting to loss of gene thyA functionality. By transformation of indicated strain with expressing vector comprising the functional gene thyA and gene encoding a homologous or heterologous protein the expression system for preparing indicated homologous or heterologous protein is created. Applying the invention provides enhancing stability of system used in expression of homologous or heterologous protein.
EFFECT: valuable properties of expression system.
8 cl, 17 dwg
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