FIELD: pharmacology.
SUBSTANCE: preparation method includes the following steps. Form 2 cyclosporin A dilution in a solution, solution autoclaving, and addiyion of a filler selected from carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, hyaluronic acid, polyvinylpyrrolidone, Carbopol Ultrez 10NF and Pluronic F127. The method can also be carried out by dilution of the said filler, addition to the Form 2 cyclosporin a solution and resulting mixture autoclaving. Form 2 cyclosporin A is characterized by crystal peaks of CDP measured at CuKα emission: 7.5, 8.8, 10.2, 11.3, 12.7, 13.8, 14.5, 15.6 and 17.5 °2θ.
EFFECT: preparation of a cyclosporin a composition with high stability relative to thermal sterilisation.
2 cl, 5 tbl, 12 dwg, 1 ex
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