CYCLOSPORINE SUSPENSIONS A OF FORM 2 Russian patent published in 2018 - IPC A61K9/00 A61K38/13 A61K47/00 A61P27/02 

FIELD: pharmacology.

SUBSTANCE: group of inventions represents: an ophthalmic suspension, containing cyclosporine A of form 2 and some medium, where cyclosporine A of form 2 is characterized by peaks in X-ray diffractometer scanning with the radiation of Cu Kα, 2θ: 7.5, 8.8, 10.2, 11.3, 12.7, 13.8, 14.5, 15.6 and 17.5; method of preparation of cyclosporine composition, which includes the stages of mixing cyclosporine A of form 2 with the medium for producing the suspension; suspension quassation; ophthalmic suspension, containing particles of cyclosporine A of form 2; and the medium, in which the average particle size (d90) is less than about 10 micron; method of treatment of a condition selected from: dry eye syndrome, blepharitis, tarsal glands disease, impaired awareness of corneal, allergic conjunctivitis, atopic keratoconjunctivitis, spring keratoconjunctivitis and pterygium, including the stage of applying said ophthalmic suspension to the patient, being in this condition.

EFFECT: increased bioavailability, reduced foreign body sensation and achieved high stability.

15 cl, 18 dwg, 2 ex, 2 tbl