METHOD FOR LUNGS PROTECTION DURING CARDIAC SURGERY WITH ARTIFICIAL CIRCULATION Russian patent published in 2017 - IPC A61B17/00 A61K47/14 A61H31/00 A61P43/00 

FIELD: agriculture.

SUBSTANCE: trachea intubation, artificial ventilation (AV) and ultra-hemofiltration are performed during artificial circulation. At the same time, after the beginning of AV and central vein catheterization, alprostadil is infused into it at a dose of 0.002-0.005 μg/kg/min during the entire operation until the patient is transferred to resuscitation. The pulmonary artery is perfused through an additional cannula mounted above the pulmonary artery valve. It is connected to an additional perfusion pump through an additional route with oxygenated blood, into which alprostadil is administered at a dose of 0.002-0.005 μg/kg/ min during the whole time of pulmonary artery perfusion, which is performed at a space velocity of 250-300 ml/min. During artificial circulation, ventilation is continued, reducing the respiratory volume to 50% of the initial, but not more than 5 ml/kg, reducing the respiratory rate to 5-6 times per minute.

EFFECT: method allows to increase the effectiveness of lungs protection by preventing an increase in the alveolar-arterial oxygen gradient, to reduce the oxygenation and pulmonary compliance index, and to increase intrapulmonary shunting after artificial circulation.

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