NEUROPROTECTIVE AGENT FROM PIG BRAIN BASED ON SODIUM MONOSIAL GANGLIOSIDE Russian patent published in 2017 - IPC A61K31/7032 A61P25/00 

FIELD: pharmacology.

SUBSTANCE: neuroprotective agent is a substance based on sodium monosialotetrahexosylganglioside obtained from the pig brain by extraction, precipitation of a gangliosides-containing mixture with a sodium hydroxide solution and its adsorption on a macroreticular ion exchange resin, followed by chromatographic separation on an ion-exchange column, selection of a fraction with sodium monosialotetrahexosylganglioside, determined by thin layer chromatography, dissolution in a mixture of trichloromethane, methyl alcohol and purified water, followed by purification using an ion exchange resin column, activated carbon, cation exchange resin column, filtration and drying, and having the following characteristics: sodium monosialotetrahexosylganglioside content of at least 96%, with a content of 19.0%-21.0% sialic acid residues based on dry matter, pH of the aqueous solution at a concentration of 20 mg per 1 ml - 5.0~6.5, the area of the impurity peak with a molecular weight of more than 5000 daltons is not more than 1.00% of the peak area of sodium monosialotetrahexosylganglioside, moisture content is not more than 5%.

EFFECT: improved compound properties.

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