FIELD: pharmacology.
SUBSTANCE: invention relates to polymeric water-soluble derivatives of 4-phenylbutanoic acid having antitumour activity based on copolymers of N-vinylpyrrolidone or N-methyl-N-vinylacetamide with N,N-dimethylaminoethyl methacrylate and/or its quaternary ammonium salt of the general formula:
.
At that, k=60-75 moll. %, l=0-17 moll. %, m=2-39 moll. %, n=0-8 moll. %.
EFFECT: new polymeric derivatives of 4-phenylbutanoic acid are characterized by good tolerability and high antitumour efficacy.
3 tbl, 10 ex
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