SKIN-PENETRATING GLYCOSAMINOGLYCAN COMPOSITIONS FOR TOPICAL APPLICATION IN COSMETICS AND PHARMACY Russian patent published in 2017 - IPC A61K47/36 A61K8/73 A61P17/00 A61Q19/08 

FIELD: pharmacology.

SUBSTANCE: glycosaminoglycan is hyaluronan or a derivative thereof and has a molecular weight of 50-2500 kDa, is treated with an activating agent that is a reaction-limiting reagent. Next, a lipid moiety containing an amino group is introduced into the reaction, lasting from 30 minutes to 3 hours, with the activated glycosaminoglycan for the their covalent binding. The molar amount of the lipid moiety in the reaction is greater than the amount of activator used, which in turn is added in an amount to promote covalent binding of the lipid fragment with 1-7.5% of disaccharide monomer units of the glycosaminoglycan; as well as to the modified glycosaminoglycan obtained by this method, to the drug on its basis and to its application.

EFFECT: improved local delivery of modified hyaluronan through the skin barrier.

27 cl, 20 ex, 17 dwg