FIELD: medicine.
SUBSTANCE: for simulation of a severe craniocerebral injury with persistent violations of neurological and cognitive functions, a one-time shock effect is provided by a free-falling load on an intact firm brain shell through a trepanation window in the front-parietal part. At that, 8-10-week-old outbreed male C57BL/6 mice with a body weight of 20-22 g are used as laboratory animals. The impact is provided with a load weighing 4 g from a height of 80 cm. The diameter of the shock part of the load corresponds to the diameter of the trephination window.
EFFECT: method provides simulation conditions that maximally reproduce the clinical picture of severe focal brain damage without the death of a laboratory animal, which is necessary for monitoring and development of methods for brain functions restoration in the post-traumatic period.
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