FIELD: medical science.
SUBSTANCE: invention refers to experimental medicine and aims at simulating a craniocerebral injury of various severities in medium and large laboratory animals. An apparatus for simulating a craniocerebral injury in medium- and large-sized animals consists of: a guide pipe made of plastic with length of 2 m and diameter of 110 mm, along the length of which, flush with the outer and inner surfaces, a strip of transparent plastic with a width of at least 5 mm is tightly embedded, and a thread is cut along the lower edge; round platform made of perforated impact-resistant plastic with diameter of 18-19 mm; impact rod made in the form of a polished metal shaft with diameter of 10 mm; gripper-claw made with locking force, allowing to hold platform with impact rod; tabletops with a through hole with diameter of 15 mm, in the lower part of which a shadowless LED illuminator and a video camera are fixed; two linear bearings with outer diameter of not less than 20 mm and inner diameter of 10 mm; device for fixing the pipe to the tabletop, made in form of 10 mm thick plate with a blind threaded connection with diameter of 110 mm, in the centre of which there is a hole with diameter of 15 mm; positioning system of the impact rod, [-shaped, the upper part of which contains three holes for screw fastening, the lower part is made in the form of a circle with diameter of 15 mm, in the centre of which there is a hole with diameter of 11 mm; fixing device, made in the form of a table on four legs, the height of each of which is adjusted independently, and on the outer surface of the table top of which there is a device for fixing animals; wherein: linear bearings are fixed in tabletop upper and lower parts; centres of pipe diameters, device for fixing pipe to tabletop, holes of tabletop, linear bearings, lower part of locking device are located coaxially along one straight line passing perpendicular to tabletop; centres of the round platform, the impact rod, the claw are located along the same straight line; on the upper surface of the platform there is a circle with diameter of 5 mm, located strictly in the centre of the circle forming the outer surface of the platform; impact rod is fixed on the lower surface of the platform so that the centre of the upper surface of the rod coincides with the centre of the circle forming the inner surface of the platform; linear bearings are fixed on the outer and inner surfaces of the tabletop so that their centres lie on one straight line with the centre of the hole of the tabletop and passing perpendicular to the tabletop; grip-claw is fixed on the inner surface of the tabletop so that the centre of the space between the jaws of the claw is on the same line as the centre of the diameter of the impact rod and passing perpendicular to the tabletop; positioning system of the impact rod is fixed to the inner surface of the tabletop so that the centre of the opening in its lower circle is on the same line as the centre of the diameter of the impact rod and passing perpendicular to the tabletop; on the outer side surface of the positioning system of the impact rod there is a measuring scale with a scale factor of 1 mm; on the outer surface of the pipe along a strip of transparent plastic there is a measuring scale with a scale factor of 1 mm; and when conducting studies: the animal is placed in the retainer, which is positioned and adjusted so that the injury point is under the centre of the opening in the lower circle of the positioning system; platform with the impact rod is placed in the hole of the tabletop so that it is held by the claw; pipe is put on platform with impact rod and is fixed to tabletop by means of threaded joint; from above, a load is dropped into the pipe so that it falls into the centre of a circle applied to the outer surface of the platform; platform begins to move, the perforated holes therein ensure the released air uniform escape from the space between the platform and the tabletop; shock rod moves along its longitudinal axis inside linear bearings, being released by gravity from grip claws, and passes through the hole in lower circle of positioning system, which provides accurate determination of injury point.
EFFECT: more accurate control of the craniocerebral injury simulation conditions of various severities in medium and large laboratory animals with provided experimental conditions reproducibility.
1 cl, 1 dwg, 1 ex
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Authors
Dates
2025-05-28—Published
2025-01-31—Filed