METHOD FOR MORPHOLOGICAL EVALUATION OF INFLUENCE OF VARIOUS DOSAGE FORMS OF IRON FOR ENTERNAL APPLICATION ON SMALL INTESTINE IN EXPERIMENTAL ANIMALS Russian patent published in 2018 - IPC A61B5/00 A61D99/00 A61K33/26 A61P1/00 A61P3/00 

FIELD: medicine.

SUBSTANCE: pathohistological examination of the small intestine tissues is performed. Morphological criteria are determined: desquamation of the mucosal epithelium, necrosis of the mucous membrane, arterial-venous hyperemia, hemorrhage, mucosal edema, hemosiderosis of enterocytes, hemosiderosis of phagocytes. Further, the criteria are scored. The degree of influence of medicinal forms of iron on the small intestine (SPK) is calculated according to the claimed formula. The value of SPK from 0 to 1.2 points inclusive is assessed as a mild injury. SPK from 1.3 to 1.9 points inclusive - as an average injury. SPK from 2.0 to 3.0 points inclusive - as a serious injury.

EFFECT: method allows to accurately and simply perform a morphological evaluation of the effect of various medicinal forms of iron for enteral administration on the small intestine in experimental animals by determining the most significant morphological criteria.

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