AURORA AND FLT3 KINASES MODULATORS Russian patent published in 2018 - IPC C07D413/14 A61K31/496 A61P35/00

Abstract RU 2643809 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of the formula

(1); where R¹ is hydrogen or C_1-2 alkyl; and R², R³ and R⁴ the same or different and each is selected from hydrogen, C_1-2 alkyl, fluorine, chlorine, C_1-2 alkoxy and trifluoromethyl, provided that no more than two of R², R³ and R⁴ are different from hydrogen. The invention relates to a pharmaceutical composition for prevention or treatment of a disease mediated by Aurora A, Aurora B kinase or FLT3 kinase, comprising a therapeutic amount of a formula (1) compound, and a pharmaceutically acceptable excipient. The compounds are intended for use in treatment of a proliferative disease, a hematopoietic tumour selected from acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), Hodgkin's lymphoma (HL), non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).

EFFECT: compounds for treatment of diseases mediated by Aurora A kinase, Aurora B or FLT3 kinase.

16 cl, 6 tbl, 18 ex

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RU 2 643 809 C2

Authors

Rider Dzhon Charlz

Dates

2018-02-06—Published

2013-02-04—Filed