AURORA AND FLT3 KINASES MODULATORS Russian patent published in 2018 - IPC C07D413/14 A61K31/496 A61P35/00

Abstract RU 2643809 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of the formula

(1); where R¹ is hydrogen or C_1-2 alkyl; and R², R³ and R⁴ the same or different and each is selected from hydrogen, C_1-2 alkyl, fluorine, chlorine, C_1-2 alkoxy and trifluoromethyl, provided that no more than two of R², R³ and R⁴ are different from hydrogen. The invention relates to a pharmaceutical composition for prevention or treatment of a disease mediated by Aurora A, Aurora B kinase or FLT3 kinase, comprising a therapeutic amount of a formula (1) compound, and a pharmaceutically acceptable excipient. The compounds are intended for use in treatment of a proliferative disease, a hematopoietic tumour selected from acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), Hodgkin's lymphoma (HL), non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).

EFFECT: compounds for treatment of diseases mediated by Aurora A kinase, Aurora B or FLT3 kinase.

16 cl, 6 tbl, 18 ex

Similar patents RU2643809C2

Title	Year	Author	Number
PHARMACEUTICALLY ACTIVE COMPOUNDS	2013	Blagg Dzhulian Bavetsias Vassilios Mur Endryu S. Linardopoulos Spiridon	RU2654942C2
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS	2006	Okram Barun Rehn' Pinda Grej Natanaehl S.	RU2387653C2
SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF THEIR APPLICATION	2012	Si Nin	RU2568258C2
PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE PREVENTION OR TREATMENT OF CANCER	2019	Bae In Hwan Kim Ji Sook Choi Jae Yul Kang Seok Jong Ahn Young Gil Suh Kwee Hyun	RU2807277C2
SUBSTITUTED INDOL-5-OL DERIVATIVES AND THERAPEUTIC APPLICATIONS THEREOF	2013	Tao Chunlin Van Tsinvej Kho Devid Polat Tulaj Nallan Laksman Soon-Shiong Patrik	RU2674249C2
SUBSTITUTED N2-(4-AMINO-2-METHOXYPHENYL)-N4-[2-(DIMETHYLPHOSPHORYL)-PHENYL]-5-CHLORO-PYRIMIDINE-2,4-DIAMINES AS MODULATORS OF ALK AND EGFR, APPLICABLE FOR TREATING CANCER	2015	Ivashchenko Aleksandr Vasilevich Ignatev Vasilij Gennadevich Repik Aleksej Evgenevich Shafeev Mikhail Ajratovich	RU2607371C1
BENZOTHIOPHENES AND RELATED COMPOUNDS AS STING AGONISTS	2019	Altman, Majkl, D. Kesh, Brendon, D. Childers, Mettyu Llojd Kamming, Dzhared, N. Demong, Duejn, E. Khejdl, Endryu Mark Khenderson, Timoti, Dzh. Dzhuvell, Dzhejms, P. Larsen, Mettyu, A. Lim, Dzhongvon Lu, Min Otte, Rajan, D. Trotter, Bendzhamin Uesli	RU2806274C2
PROTEIN TYROSINE KINASE ACTIVITY INHIBITORS	2009	Majkl Mannion Stefan Rappel' Stiven Uill'Jam Klaridzh Frederik Godett Litszi Chzhan' Ljubomir Isakovits Oskar Mario Saavedra Tetsujuki Uno Masashi Kishida Arkadij Vajsburg	RU2533827C2
CHEMICAL COMPOUNDS-759	2008	Dejvis Odri Ioannidis Stefanos Lamb Mishell' Su Mehj Van Tao Chzhan Khajtszun'	RU2481348C2
MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR	2011	Lau Dzhonson Khuan Tszjann'-Dzikh	RU2576036C2

RU 2 643 809 C2

Authors

Rider Dzhon Charlz

Dates

2018-02-06—Published

2013-02-04—Filed