BIOMARKER SAMPLES SELECTION AS PART OF DEVICES FOR NEUROMODULATION AND RELEVANT SYSTEMS AND METHODS Russian patent published in 2018 - IPC A61B18/14 

FIELD: medicine.

SUBSTANCE: catheter system includes an element for neuromodulation containing one or more energy delivering elements, the neuromodulation element being designed to modulate nerves located on or otherwise approximated to the patient's renal artery, supporting structure, bearing the energy delivering elements with a cavity comprising wires electrically connected to the energy delivering elements and a control element within the cavity defining the passage, an elongated barrel with a distal part designed for intravascular placement, wherein the neuromodulation element modulates the nerves, and a proximal part designed for in vitro placement, when the neuromodulation unit modulates the nerves, an occlusal element extending around the distal part segment, a sampling port located distally from the distal part segments, a sampling cavity extending from the sampling port towards the proximal part, an inflation port in the occlusal element and a cavity for inflation extending from the inflation port toward the proximal part. In the second version, the catheter system includes a neuromodulation and sampling unit connected to the stem through the distal part including an energy delivering element designed to modulate nerves at least proximally to the patient's artery, a sampling port designed for intravascular sampling of a patient's biological sample at or near the treatment site, an analyser operatively connected to the barrel and designed to receive at least a portion of a biological sample and indication of the biological sample status and/or nerve modulation status based on the biological sample. In the third version of the catheter system, there is an occlusal element proximal to the sampling port, where the occlusal element has one or more pressure sensors, a controller operatively connected to one or more pressure sensors including a memory and a processing loop, wherein the memory stores instructions that, when performed by the controller using the processing loop, cause the controller to receive pressure measurement data from the occlusal element through one or more pressure sensors, and the occluding member to expand to a volume based on the pressure measurement results from the occlusal element. The system for renal neuromodulation includes a neuromodulation element designed to modulate nerves located on or otherwise approximated to the patient's renal artery, an elongated barrel, an occlusal element extending around the distal part segment, a sampling port located distally from the distal part segment, a sampling cavity extending from the sampling port towards the proximal part, an inflation port in the occlusal element, an inflation cavity extending toward the proximal part, an analyser designed to analyse a patient's biological sample for a biological parameter that changes in response to nerve modulation, an elongation for sampling with a distal sampling element designed for distal expansion from the stem behind the neuromodulation element in the interlobar vessel of the patient's kidney when the occlusal element at least partially covers the renal artery and a sampling port, transferable by the distal sampling element. In the second version of the system, there is the second elongated barrel having the second distal end coupled to the neuromodulation element and constructed to expand as it slides through the said cavity so that the second distal end portion extends through the said opening. In the third version of the system, there is an intravascular catheter with a handle on the proximal portion, a neuromodulation and sampling element on the distal part, and an elongated barrel between them, the neuromodulation and sampling unit further comprise a cantilever operatively connected to a handle designed to supply energy to the neuromodulation element, and an analyser functionally connected to the barrel and designed to detect biomarker concentration in the blood sample from the kidney, where the concentration corresponds to the degree of kidney nerves modulation.

EFFECT: application of inventions allows to facilitate the analysis of neuromodulating efficiency.

27 cl, 9 tbl, 81 dwg