METHOD FOR THE PREPARATION OF PAPAVERINE HYDROCHLORIDE Russian patent published in 2018 - IPC C07D217/20 

FIELD: chemistry.

SUBSTANCE: invention refers to the field of organic chemistry, namely to the process for the preparation of papaverine hydrochloride, which is carried out as follows, trichlorethylene, veratrol and paraformaldehyde are charged into the reactor, the reaction mixture is heated up to the temperature of 35±10°C, then hydrogen chloride is fed into the reaction mixture, heating at the temperature of 55±5°C is carried out for 1.0-3.0 h, it is followed by washing with purified water, the reaction mixture is cooled up to the temperature of 15±8°C; chloromethylation of veratrol 3,4-dimethoxybenzyl chloride is carried out, further cyanation with chloromethylation of veratrol 3,4-dimethoxybenzyl chloride, then vacuum-distillation of homonitrile is carried out and homoveratric acid is produced; then 3,4-dimethoxyphenylethylamine is obtained, followed by condensation of 3,4-dimethoxyphenylethylamine with homoveratric acid, 3,4-dimethoxyphenyl-ethylamide 3,4-dimethoxyphenylacetic acid is obtained, further on, 6,7-dimethoxy-1-(3,4-dimethoxybenzyl) isoquinoline is obtained, its purification is carried out and papaverine hydrochloride is isolated with the alcoholic solution of hydrogen chloride.

EFFECT: technical result: the new method for obtaining pharmacopeia papaverine chloride with the high yield of the finished product has been developed.

4 cl