METHOD FOR OBTAINING A STREPTOCIDE SOLUBLE Russian patent published in 2018 - IPC A61K31/63 C07C303/00 C07C311/39 

FIELD: medicine; pharmacology.

SUBSTANCE: present invention relates to the field of pharmacology and discloses a process for the preparation of a soluble streptocide. Method is characterized in that sodium pyrosulphite is dissolved in water, formalin is added, at pH 8.0-10.0 of the reaction mass, active carbon is added and the mass is kept with stirring for 1-1.5 hours, water and streptocide are added, the reaction mass is stirred, sulfuric acid is gradually added until the reaction mass is reached pH of 3.0-4.0, followed by heating and soaking, active carbon is loaded, the pH of the reaction mixture with sulfuric acid is adjusted to 3.0-4.5, preheated isopropyl alcohol is charged, the reaction mass is stirred and kept under intermittent stirring, after the end of aging, the reaction mass is cooled, washed with isopropyl alcohol, dried and milled.

EFFECT: method makes it possible to obtain a product of compendial grade and can be used in the pharmaceutical industry for the manufacture of ready-to-use combined medicines in the form of solutions, aerosols, sprays, liniments containing streptocide soluble.

1 cl