SPECIFIC PEPTIDE CLATHRIN INHIBITORS Russian patent published in 2018 - IPC A61K38/08 C07K7/06 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and chemical-pharmaceutical industry. Proposed is use of synthetic peptides as specific clathrin inhibitors. Synthetic peptides are a peptide of general structure (I): XDL – XDL1 – XDL2 – L-Lys – L-Leu – XDL3 – L-Thr – R2 [SEQ ID NO: 1] or a peptide – retro-inversion of structure (I), having an inverse amino acid sequence replacing the L-form of the amino acids by the D-form and the D-form of the amino acids by the L-form, of general structure (II): D-Thr – XDL4 – D-Leu – D-Lys – XDL5 – XDL6 – XDL7 – R2 [SEQ ID NO: 2], where the values of XDL1-7 are presented in the formula.

EFFECT: proposed peptides have a high affinity for the heavy chain of clathrin and can be used to isolate the heavy chain of clathrin, as well as to create new drugs that are specific clathrin inhibitors.

1 cl, 4 dwg, 1 tbl, 2 ex