MICRONEEDIC APPLICATOR AND METHOD OF ITS MANUFACTURE Russian patent published in 2018 - IPC A61M37/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to injection devices. Microneedic aplicator comprises a microneedic template containing more than one micro-needles, made biodegradable and carrying a drug, and a substrate. Microneedles of the matrix consist of two parts, the first part that faces the point of the microneedle is 60–95 % of the microneedle height and is made from a mixture of a carrier biodegradable agent and a drug, second part, making up the remaining height of the microneedle to the base of the microneedle, is made of a biodegradable component, as a substrate, the microneedic applicator comprises a layer made of a biodegradable component or an insoluble agent, ratio of the specific dissolution rates of a carrier biodegradable agent and a biodegradable component is 1:200,000÷950,000 respectively. In the manufacture of a microneedic applicator, microneedles of a micro needle matrix are made in two parts height long, to form the first part, a mixture of a carrier bioresorbable agent and a drug is placed in the cone-shaped mold cavities to a height of 60–95 % of these wells height, mixture is kept at a negative pressure and dehydration process is carried out at a temperature of +22÷90 °C for 8÷72 hours; to form the second part, the remaining volume of the wells is filled with a biodegradable component, also it is held at negative pressure, then the process of dehydration is carried out at a temperature of +22÷90 °C for 8÷72 hours, a substrate is placed above the wells.

EFFECT: group of inventions allows to reduce the reaction to a foreign body, to control the release time of a drug.

22 cl, 2 dwg, 1 tbl