FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology and genetic engineering, in particular to genetically modified rodents, such as a mouse and a rat, which express a chimeric human/non-human MHC I polypeptide and/or a human polypeptide β2 microglobulin, as well as to cells of such rodents. Present invention discloses methods obtaining said animals, as well as a method for identifying the CTL epitope, and a method of identifying an HLA class I peptide restricted using same.
EFFECT: present invention allows the production of biological systems that will create an immune system that exhibits components that mimic the function of the human immune system.
62 cl, 10 dwg, 3 ex, 1 tbl
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