FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a rodent containing in the endogenous microglobulin β2 locus a nucleic acid sequence containing exon 1 of the endogenous rodent β2 microglobulin gene, functionally linked to a nucleic acid containing sequences presented in exon 2, exon 3 and exon 4 genes β2 human microglobulin.
EFFECT: invention is effective as a biological system that can create an immune system that exhibits components that mimic the function of the human immune system.
6 cl, 10 dwg, 1 tbl, 3 ex
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