DERMAL INJECTABLE STERILE COMPOSITION Russian patent published in 2018 - IPC C08B37/08 

FIELD: medicine.

SUBSTANCE: present invention relates to a crosslinked hyaluronic acid gel. Crosslinked hyaluronic acid gel is derived from the crosslinking of hyaluronic acid or a salt thereof in the presence of at least an effective amount of at least one endogenous polyamine as a crosslinking agent. Said crosslinking is carried out in the presence of at least one activator or in the presence of at least one activator in combination with at least one auxiliary coupling agent for carrying out a covalent coupling reaction of said hyaluronic acid and said endogenous polyamine(s). Said gel has a degree of modification of less than or equal to 1%, the degree of modification being the ratio between the number of moles of endogenous polyamine attached to the hyaluronic acid and the number of moles of hyaluronic acid forming said crosslinked gel.

EFFECT: invention enables to obtain a crosslinked hyaluronic acid gel with the lowest degree of modification, but with satisfactory mechanical properties and high resistance to sterilisation.

19 cl, 4 tbl, 2 ex