MEDICINAL PRODUCT FOR TREATMENT OF BREAST CANCER Russian patent published in 2018 - IPC A61K47/40 B82B1/00 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to pharmaceutical industry and can be used to treat breast cancer as an intravenous drug without any external influence (heating, magnetic field, etc.). Medicinal preparation for the treatment of breast cancer includes magnetic iron oxide nanoparticles Fe₃O₄, coated with a protective coating and associated with monoclonal antibodies and doxorubicin. According to invention, the containment shell is formed from bovine or human serum albumin (BSA or HSA) and polyethylene glycol (PEG), monoclonal antibodies are monoclonal antibodies to the vascular endothelial growth factor (VEGF), and nanoparticles are associated with doxorubicin non-covalently, mainly due to electrostatic interactions, with the following ratio of components, mass%: iron oxide Fe₃O₄ 30–40; BSA or HSA 40–50; PEG 5–10; doxorubicin 5–10 and antibodies to VEGF 0.5–1.0.

EFFECT: invention allows to improve delivery of the active substance to tumor cells, to increase the release efficiency of the active substance, which leads to an increase in the efficacy of chemotherapy and a reduction in its side effects.

1 cl, 3 dwg, 1 tbl