FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, specifically phthisiology, and can be used to treat active tuberculosis infection. Methods of the invention comprise administering to a mammal an immunologically effective amount of a therapeutic vaccine comprising an isolated fusion polypeptide comprising a combination of antigens Rv1813, Rv3620, Rv3619 and Rv2608 in combination with chemotherapeutic agents.
EFFECT: use of the inventions prolongs survival when treating an active tuberculosis infection and shortens the duration of chemotherapy.
41 cl, 4 tbl, 32 dwg, 6 ex
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