METHOD FOR PREDICTING THE EFFECTIVENESS OF TREATMENT WITH IMMUNOVENIN IN DISIMMUNOGLOBULINEMIA DUE TO THE REACTIVATION OF CHRONIC HERPESVIRUS INFECTION IN WOMEN IN THE SECOND TRIMESTER OF PREGNANCY Russian patent published in 2018 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to obstetrics, and relates to a method for predicting the efficacy of treatment with immunovenin in disimmunoglobulinemia due to the reactivation of chronic herpesvirus infection in women in the second trimester of pregnancy. Method comprises: in blood serum before the treatment with immunovenin, IgM and IgG antibodies to the herpes simplex virus (HSV 1 and 2 types) and to the cytomegalovirus (CMV) with the avidity index of IgG to HSV and CMV are more than 65 % in points (1 point – IgM and IgG to HSV 1 type, IgG to HSV type 2; 2 points – IgM and IgG to HSV type 1, as well as IgM and IgG to HSV type 2; 3 points – IgM and IgG to HSV type 1, IgM and IgG to HSV type 2, and IgG to CMV) (A); serum IgG level (mg/l) (B); concentration of C-reactive protein (CRP) (mg/l) (C); frequency of development of acute respiratory viral infections (ARI) during the year in points (1 point - ARVI 1-2 times a year; 2 points – SARS 3-4 times a year; 3 points – SARS 5 times or more per year) (E), and then with the help of the discriminant equation, including the determined indicators, predict the effectiveness of immunovenin treatment of disimmunoglobulinemia:D=-2.333×A-1.514×B-0.492×C-3.533×E, where D is a discriminant function with a boundary value of – 25.00. If D is less than the limiting value of the discriminant function, ineffective treatment with immunovenin of disimmunoglobulinemia is predicted, and at D equal to or greater than the limiting value, an effective treatment with immunovenin of disimmunoglobulinemia due to the reactivation of chronic herpesvirus infection in women in the second trimester of pregnancy is predicted. Probability of a correct forecast is 86.2 %.

EFFECT: invention provides a prognosis of the effectiveness of treatment with immunovenin of disimmunoglobulinemia in women with the reactivation of chronic herpesvirus infection in the second trimester of pregnancy.

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