FIELD: medicine.
SUBSTANCE: invention relates to medicine, in particular to a method for obtaining an injectable resorbable implant for the treatment of mild types of urinary stress incontinence and connective tissue deficiency based on polycaprolactone and multipotent stormal cells from umbilical cord. Method is characterized in that polycaprolactone is monolithized by supercritical fluid technology, monolith of polycaprolactone is ground, and fractions of 100–150 mcm are selected, cell culture of multipotent human stromal cells is obtained, the cellular and matrix components of the structure are combined, the polycaprolactone particles with adherent cells are transferred, polycaprolactone particles are transferred to an administration medium and an implant of polycaprolactone particles of 100–150 mcm is obtained in the administration medium consisting of hypromellose or carboxymethylcellulose, or sodium hyaluronate, or polyvinylpyrrolidone, or glycerol, or combinations thereof.
EFFECT: invention provides a bioresorbable implant to restore the volume and density of connective tissue of an organ wall having a high biocompatibility.
2 cl, 2 ex, 13 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR A BIORESORABLE MESH IMPLANT OBTAINING FOR THE PELVIC WALLS AND ABDOMINAL CAVITY PLASTIC RECONSTRUCTION | 2016 |
|
RU2648355C1 |
| METHOD FOR PREPARATION OF MULTIPOTENT STROMAL CELLS FROM CRYO-FROZEN FETOPLACENTAL COMPLEX TISSUES | 2015 |
|
RU2610132C1 |
| METHOD FOR OBTAINING MULTIPOTENT MESENCHEMIC STROMAL CELLS FROM UMBILICAL CORD OF NEWBORN | 2020 |
|
RU2744301C1 |
| BIOTRANSPLANT BASED ON FOAMED CERAMIC CARRIERS OF ZIRCONIUM OXIDE AND ALUMINIUM OXIDE SYSTEM AND MULTIPOTENT STROMAL CELLS OF HUMAN BONE MARROW FOR RESTORING EXTENDED BONE TISSUE DEFECTS AND METHOD FOR MAKING THEREOF | 2008 |
|
RU2386453C1 |
| BIOACTIVE RESORBED POROUS 3D-MATRIX FOR REGENERATIVE MEDICINE AND METHOD FOR PREPARING IT | 2013 |
|
RU2533457C1 |
| BIOACTIVE POLYMER POROUS STENTS | 2016 |
|
RU2665175C2 |
| METHOD FOR OBTAINING A SUSPENSION OF SINGLE VIABLE CELLS FROM CELLULAR SPHEROIDS | 2021 |
|
RU2779742C1 |
| METHOD OF USING MESENCHYMAL STEM CELLS FOR IMPROVING UTERINE SCAR CONDITION | 2018 |
|
RU2699029C1 |
| CELL-FREE THERAPEUTIC AGENTS FOR REGENERATIVE MEDICINE AND METHODS FOR PREPARING THEM | 2018 |
|
RU2742034C2 |
| CELL CULTURE AND BIOTRANSPLANT FOR BONE TISSUE REGENERATION ON ITS BASIS | 2017 |
|
RU2675930C1 |
