FIELD: medicine.
SUBSTANCE: invention relates to medicine, in particular to the production of biocompatible stents for the bone tissue defect restoration. Biocompatible stent in the form of a bioresorbable porous structure for medical purposes with increased osteoconductivity based on a thermoplastic polymer with the addition of a bioactive ceramic component can be populated with multipotent mesenchymal stromal cells of mammals and consists of a polymer matrix of a polylactide and bioactive filler of hydroxyapatite with an average particle size of 100 to 1000 nm with increased adhesion to the polymer matrix. Said stent is formed by 3D printing by fusing filaments with a layer thickness of 50–250 mcm and is characterized by the presence of open porosity of 30 to 60 vol. % and pores in the form of channels with an average diameter of 400–800 mcm.
EFFECT: bioactive polymer stent is characterized by fact that its operation is possible at a temperature of up to 55 °C without changing the functional characteristics of the stent, can be populated with multipotent mesenchymal stromal cells of mammals for use as an implant to restore bone defects.
3 cl, 9 dwg, 2 ex
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Authors
Dates
2018-08-28—Published
2016-06-10—Filed