FIELD: organic chemistry.
SUBSTANCE: invention relates to a group of compounds of formula (I) containing a chromene nucleus or pharmaceutically acceptable salts thereof, wherein: R1 is unsubstituted C1-C6 alkyl or C1-C6 alkyl substituted with C3-C6 cycloalkyl; X is selected from -OH or -N(R2)(R3); R2 and R3 are independently selected from hydrogen, unsubstituted C1-C6 alkyl, C1-C6 alkyl substituted with -N(R')(R''), where R' and R'' are independently selected from H or C1-C4 alkyl, or a saturated 6-membered heterocycle that contains an N atom that is unsubstituted or substituted with C1-C4 alkyl; or R2 and R3 together with the nitrogen atom to which they are attached form a 5- or 6-membered saturated heterocycle, wherein said heterocycle contains at least one heteroatom selected from nitrogen, oxygen or sulphur, and wherein the heterocycle is optionally substituted with C1-C4 alkyl; R4 is a halogen, as well as a process for their preparation. 
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EFFECT: said compounds have the ability to inhibit the proliferation of lymphocytes mediated by the interaction of TCR with Nck, and therefore the present invention also relates to pharmaceutical compositions based thereon and the use of these compounds for the treatment of diseases or conditions, in which said interaction causes complications, such as graft rejection reactions, immune or autoimmune diseases, inflammatory diseases or proliferative diseases.
36 cl, 2 dwg, 3 ex
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