METHOD FOR SUBSTANTIATING THE OCCURRENCE OF A NEGATIVE EFFECT IN CHILDREN IN FORM OF A DISEASE ASSOCIATED WITH THE CENTRAL OR AUTONOMIC NERVOUS SYSTEM ASSOCIATED WITH AEROGENIC EXPOSURE OF ALUMINUM Russian patent published in 2018 - IPC A61B5/00 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Allocate territory with a permanent presence of aluminum and establish a list of the most likely negative effects – health disorders in children associated with increased aerogenic exposure of aluminum. As a negative effect, the diseases associated with the central nervous system and the ANS are taken. Form an observation group from the children from the exposition area and a comparison group from children from the territory of ecological well-being. Establish the leading diseases of the CNS and VNS in each group. Form a list of laboratory and functional indicators associated with the leading negative effect. Samples of urine and blood are collected from children from both groups. Determine the urine content of aluminum, and in the blood – the levels of laboratory indicators. Functional indicators are determined by instrumental methods. Mathematical formula calculates the probability P'_k the deviation of the k-th index of the leading negative effect from the physiological norm with an elevated relative to the reference level of aluminum in the urine, establishing specified laboratory and functional indicators. Further, according to the mathematical formula, the probability P''_k development of the leading negative effect at the established level of the k-th refined index. Indicators, which in this case will be reliably inherent in the leading negative effect, are referred to a set of marker laboratory and functional indicators. Calculate the overall probability P of the leading negative effect at an elevated relative to the reference level of aluminum in the urine. Determine the degree of association of the leading negative effect with the aerogenic effect of aluminum compounds: at P less than 0.05 – negligible, at P 0.05–0.35 – average, at P from more than 0.35 to 0.6 inclusive – high, at P more than 0.6 – very high. Association of the leading negative effect in the form of CNS or VNS disease associated with prolonged aerogenous exposure to aluminum is considered reasonable with the simultaneous content of more than 0.0065 mg/dm³ of aluminum, presence of deviations from the physiological norm of all marker laboratory and functional indices, which are authentically inherent in the leading negative effect and the quantitative value of the total probability P>0.05.

EFFECT: method allows to substantiate informatively and demonstratively the occurrence of a negative effect in children in the form of a disease related to the central nervous system or VNS associated with aerogenic exposure of aluminum due to the evaluation of the complex of the most significant indicators.

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