FIELD: medicine.
SUBSTANCE: proposed group of inventions relates to medicine. Methods of immobilizing an active agent to a substrate surface are proposed. Proposed substrate comprises a layer of a primer compound including a compound bound to the said layer selected from the group consisting of gallic acid, gallamide, 5-methylbenzene-1,2,3-triol, 3,4,5-trihydroxybenzaldehyde, 2,3,4-trihydroxybenzaldehyde, gallacetophenone, 3,4,5-trihydroxybenzamide, 2,3,4-trihydroxybenzoic acid, 5-hydroxydopamine hydrochloride, methylgallate, pyrogallol, their salts and combinations. Medical device containing the aforementioned substrate is proposed.
EFFECT: proposed group of inventions provides effective means and methods for hemodialysis and other applications involving contacting physiological fluids, such as blood, or tissues and a medical device or a medical device component.
72 cl, 2 dwg, 1 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ADVANCED IMMOBILIZED BIOLOGICAL OBJECTS | 2012 |
|
RU2625756C2 |
| MATERIALS AND METHODS ASSOCIATED WITH LINKERS FOR USE IN DRUG AND PROTEIN CONJUGATES | 2015 |
|
RU2737553C2 |
| MIDKINE APTAMER AND USE THEREOF | 2007 |
|
RU2460794C2 |
| GLYCO-PEG GRANULOCYTE COLONY-STIMULATING FACTOR | 2004 |
|
RU2400490C2 |
| GLYCOPOLYSIALYLATION OF PROTEINS, WHICH ARE NOT BLOOD CLOTTING PROTEINS | 2010 |
|
RU2533619C2 |
| FAST-ACTING SEALING AND THE METHODS OF ITS APPLICATION AND PRODUCTION | 2007 |
|
RU2442612C2 |
| THROMBIN DERIVATIVE AND PHARMACEUTICAL FORMULA CONTAINING IT | 2005 |
|
RU2372402C2 |
| NEW HEPARIN PARTICLES AND METHODS FOR USING THEM | 2010 |
|
RU2576803C2 |
| PHARMACEUTICAL COMPOSITION, POSSESSING ANTICOAGULANT AND CHOLESTEROL-LOWERING PROPERTIES | 2007 |
|
RU2414907C2 |
| VERSIONS OF DISINTEGRIN AND THEIR PHARMACEUTICAL APPLICATION | 2015 |
|
RU2685869C1 |
