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(19)

(11)

2 671 089

(13)

(51)

IPC

C07K16/08(2006-01-01)

C07K16/28(2006-01-01)

C07K16/46(2006-01-01)

C07K19/00(2006-01-01)

A61K39/395(2006-01-01)

A61K47/66(2017-01-01)

A61P31/20(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

(21) (22)

Application

2016114504, 2014-09-16

(24)

Start date

2014-09-16

(22)

Actual filing date

2014-09-16

(45)

Published

2018-10-29

(72)

Inventor

Prottser UlrikeBone FeliksMomburg FrankMoldenkhauer Gerkhard

(73)

Holder

Khelmkholtts Tsentrum Myunkhen Dojches Forshungstsentrum Fyur Gezundkhajt Und UmveltDojches Krebsforshungstsentrum

BI- OR MULTISPECIFIC POLYPEPTIDES BINDING IMMUNE EFFECTOR CELL SURFACE ANTIGENS AND HBV ANTIGENS FOR TREATMENT OF BV INFECTIONS AND ASSOCIATED CONDITIONS Russian patent published in 2018 - IPC C07K16/08 C07K16/28 C07K16/46 C07K19/00 A61K39/395 A61K47/66 A61P31/20 C12N15/13 C12N15/63 C12N5/10

Abstract RU 2671089 C2

FIELD: medicine.

SUBSTANCE: present invention relates to immunology. Proposed is a polypeptide capable of binding to the surface antigen of the hepatitis B virus (HBV) and a surface antigen presented by immune effector cells. Also, contemplated is a nucleic acid encoding said polypeptide; a complex containing two polypeptides; an immune effector cell, and compositions for treating and preventing HBV infection and / or a condition caused by said HBV infection, in particular liver cirrhosis, hepatocellular carcinoma, and liver cancer.

EFFECT: polypeptide of the present invention provides a specific lysis of the infected HBV cells and can find further application in the treatment of diseases caused by HBV infection.

16 cl, 16 dwg, 4 ex

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RU 2 671 089 C2

Authors

Prottser Ulrike

Bone Feliks

Momburg Frank

Moldenkhauer Gerkhard

Dates

2018-10-29—Published

2014-09-16—Filed