METHOD FOR PREDICTING SEVERE JAUNDICE OF BENIGN GENESIS Russian patent published in 2019 - IPC G01N33/50 G01N33/53 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is a method for diagnosing severe obstructive jaundice of benign genesis, characterized in that the absolute amount of pan-markers of T-lymphocytes and natural killer cells (NK-cells) is determined by the method of indirect immunofluorescence in the blood, the levels of immunoglobulin IgG and cytokines – interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α) in the serum is determined by immunoassay, in erythrocytes, the content of malondialdehyde (MDA) and the activity of superoxide dismutase and catalase enzymes (SOD-CAT) are determined by a spectrophotometric method and with the absolute number of T-lymphocyte cells below 0.47×10⁹/l, NK cells below 0.14×10⁹/l, IgG level above 5 g/l, IL-10 above 30 pg/mg, TNF-α above 2 pg/ml, MDA above 40 nmol/1 g Hb, SOD activity below 600 units/min /1 g Hb, CAT below 0.8 mmol/s/1 g Hb a severe course of mechanical jaundice of benign genesis is predicted.

EFFECT: invention provides the possibility of early diagnosis of severe jaundice of benign genesis and improving the accuracy of this diagnosis.

1 cl, 2 ex