ANALYTE IN BLOOD PLASMA CONCENTRATION MEASUREMENT METHOD Russian patent published in 2019 - IPC G01N21/21 

FIELD: measurement technology.

SUBSTANCE: invention relates to the field of materials study and analysis, and in particular, to the suspended in a liquid nanoparticles parameters measuring methods by optical methods, and can be used for the analyte in blood plasma concentration determination. Method comprises the metal elongated nanoparticles-probes initial colloidal solution preparation, which nanorod length is exceeding the width for not less than 3 times, on the nanoprobes surface the receptor molecules are fixed, selectively connected to the analyte molecules; using the laser correlation spectrometer the initial solution autocorrelation function g_VH0(τ) measurement in the range of delay times τ from 1 mcs to 10 ms for the scattered radiation component; the initial hydrodynamic radius R_H0 calculation; adding the blood plasma sample to the initial solution and the resulting solution incubation at a given temperature; similarly measuring the autocorrelation function g_VH1(τ) and the hydrodynamic radius R_H1 calculating for the resulting solution; determining the desired analyte concentration in the blood plasma by the R_H0 and R_H1 values difference_.

EFFECT: technical result consists in the ability to obtain the most accurate analyte concentration values for the blood plasma slightly diluted or undiluted samples.

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