APPLICATION OF ANTAGONISTS ACTIVATED BY PROTEASE RECEPTORS 1 (PAR-1) FOR PREVENTION AND/OR TREATMENT OF FUNCTIONAL PATHOLOGICAL CONDITION IN PELVIC AND PERINEAL REGIONS Russian patent published in 2019 - IPC A61K31/495 A61K31/5377 A61K31/443 A61P13/10 A61P15/12 A61P15/00 A61P13/00 

Abstract RU 2678309 C1

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine. Use of a PAR1 antagonist selected from vorapaxar, atopaxar, 3-(2-chlorophenyl)-1-[4-(4-fluorobenzyl)piperazin-1-yl]propenone and their pharmaceutically acceptable salts as a drug for the prevention and/or treatment of a functional pathological condition in the pelvic and perineal region, selected from the group irritable bladder syndrome, overactive bladder syndrome, chronic pelvic and perineal pain and urinary incontinence, and a pharmaceutical composition of the same purpose based on these compounds.

EFFECT: technical result consists in reducing the enhanced contractile reactions of the inflamed or overactive bladder.

15 cl, 12 dwg

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RU 2 678 309 C1

Authors

Le Gran Bruno

Zhunkuero Dide

Monzhoten Nikolya

Dates

2019-01-25Published

2014-10-31Filed