METHOD FOR PRODUCTION LIQUID PROBIOTIC PREPARATION Russian patent published in 2019 - IPC A61K31/00 A61K35/74 A61K35/741 A61K35/742 A61K35/747 

Abstract RU 2678978 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to the pharmaceutical industry, in particular to a method for producing a liquid probiotic preparation. Method of obtaining a liquid probiotic preparation, including the selection of cultures of microorganisms Lactobacillus acidophilus Scav. B-4625, Rhuminococcus albus Kr and Bacillus subtilis B-8130, selection of optimal nutrient media for their deep cultivation, mixing of the obtained culture liquids, also at the stage of mixing under sterile conditions into a mixture of culture liquids to ensure the shelf life of the biological product up to 28 days and reducing the contamination of conditionally pathogenic microflora a preservative at a dose of 0.5 g/l; 1–2 g/l is added, nipagin is used as a preservation.

EFFECT: method described above allows to exclude possible contamination of the liquid probiotic preparation with conditionally pathogenic microflora and to ensure a long shelf life.

1 cl, 7 tbl

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RU 2 678 978 C2

Authors

Lysenko Yurij Andreevich

Koshchaev Andrej Georgievich

Nosenko Anna Viktorovna

Ponomareva Liliya Olegovna

Sapegina Viktoriya Vyacheslavovna

Luneva Albina Vladimirovna

Mishchenko Valentin Andreevich

Dates

2019-02-05Published

2017-01-11Filed