FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to bicistronic vectors for the expression of toll-like receptors, and can be used in medicine for treating cancer. Bicistronic vector is constructed for expression of a toll-like receptor and its agonist in a mammal, cells of which have a high level of Coxsackie and adenovirus (CAR) receptor expression. Vector contains the first and second nucleic acids and the ubiquitin C promoter operably linked to the second nucleic acid. First nucleic acid encodes a toll-like receptor – TLR5, and the second nucleic acid encodes a toll-like receptor agonist – flagellin.
EFFECT: invention provides specific destruction of cancer cells by NF-κB-mediated apoptosis.
15 cl, 19 dwg, 6 ex, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-TUMOR EFFECTS OF A VIRAL VECTOR ENCODING A TOLL-LIKE RECEPTOR AND A TOLL-LIKE RECEPTOR AGONIST | 2017 |
|
RU2741228C2 |
| MEDICINAL PRODUCT | 2017 |
|
RU2759728C2 |
| INDUCTION OF APOPTOSIS IN TUMOUR CELLS, EXPRESSING TOLL-LIKE RECEPTOR | 2005 |
|
RU2401661C9 |
| PROSTATE-ASSOCIATED ANTIGENS AND IMMUNOTHERAPEUTIC REGIMENS BASED ON VACCINES | 2013 |
|
RU2737765C2 |
| PROSTATE-ASSOCIATED ANTIGENS AND IMMUNOTHERAPY SCHEMES BASED ON VACCINES | 2013 |
|
RU2609651C2 |
| MEDICAMENT | 2016 |
|
RU2709015C2 |
| COMPOSITION FOR AMPLIFICATION OF TRANSGENE EXPRESSION IN EUCARIOTIC CELLS, AND METHOD FOR INCREASING GENERATION OF TARGET PROTEIN CODED WITH TRANSGENE | 2013 |
|
RU2546249C2 |
| BROAD-SPECTRUM M2 PROTEIN ECTODOMAIN AVIAN INFLUENZA TYPE A VACCINE | 2014 |
|
RU2571944C1 |
| COMBINATION OF AN IMMUNE CHECKPOINT MODULATOR AND A COMPLEX CONTAINING A CELL-PENETRATING PEPTIDE, A CARGO MOLECULE, AND A TLR PEPTIDE AGONIST, FOR APPLICATION IN MEDICINE | 2017 |
|
RU2769314C1 |
| COMBINATION OF IMMUNE CHECKPOINT MODULATOR AND COMPLEX CONTAINING CELL-PENETRATING PEPTIDE, CARGO MOLECULE, AND TLR PEPTIDE AGONIST FOR MEDICAL USE | 2017 |
|
RU2748378C2 |
