METHOD FOR PREDICTION OF A NON-DEVELOPING PREGNANCY Russian patent published in 2019 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medical diagnostics, can be used for prediction of non-developing pregnancy. Method for prediction of non-developing pregnancy involves RNA isolation from cervical channel epithelial cells at 6–10 weeks of pregnancy, reverse transcription to obtain cDNA, TLR2, TLR10 and IDO expression by a quantitative polymerase chain reaction, age estimate of menarche and prognosis of developing non-developing pregnancy on the basis of equations obtained by discriminant analysis: -for non-developing pregnancy: y₁=40.13+(-1058.06*x₁)+56.10*x₂+0.01*x₃+5.8*x₄; -for progressing pregnancy: y₂=-32.0163+80.7501*x₁+24.1316*x₂+0.0080*x₃+5.1076*x₄, where x₁ TLR2 mRNA expression level (relative units), x₂ TLR10 mRNA expression level (relative units), x₃ is an IDO mRNA expression level (po units), x₄ – age of menarche, at that, if y₁ greater than y₂, a high risk of developing a miscarriage is predicted, and if y₁ less than y₂, normal course of pregnancy is predicted.

EFFECT: what is presented is a method for prediction of non-developing pregnancy.

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