FIELD: chemistry.
SUBSTANCE: present invention relates to a compound of formula (I) or mesomer thereof:
,
where mCat+ or mAn- is an organic or inorganic positive/negatively charged counterion, and m is integer from 0 to 2; p is integer from 1 to 2; q is integer from 1 to 5; alk is a carbon chain containing 1 to 5 carbon atoms; Y is O or CH2; Z is OH; n is 0 or 1; X is OH or O-; Ra1 is SO3- or additional C6-cycle condensed with adjacent carbon atom, where additional cycle contains SO3-; Ra2 is H; Rc1 is C1-C6 alkyl; Rc2 is C1-C6 alkyl or group C1-C6 alkylsulphonic acid. Invention also discloses use of a compound of formula (I) for labelling a nucleotide or an oligonucleotide and using a nucleotide.
EFFECT: disclosed compounds can be used as fluorescent labels for nucleotides used in sequencing nucleic acids.
21 cl, 5 dwg, 2 tbl
Title | Year | Author | Number |
---|---|---|---|
MULTIPLEX FLUORESCENT DETECTION OF ANALYTES | 2020 |
|
RU2816515C2 |
COUMARINS SUBSTITUTED WITH SECONDARY AMINES AND THEIR USE AS FLUORESCENT LABELS | 2018 |
|
RU2756272C2 |
NUCLEOSIDES AND NUCLEOTIDES WITH 3'-HYDROXY BLOCKING GROUPS AND THEIR USE IN METHODS OF SEQUENCING POLYNUCLEOTIDES | 2019 |
|
RU2818762C2 |
MODIFIED NUCLEOTIDE LINKERS | 2015 |
|
RU2699993C2 |
NEW COMBINATIONS OF ANTIGUANT AND REPORTER DYE | 2019 |
|
RU2795062C2 |
CHARGE LABELLED NUCLEOTIDES AND METHODS FOR APPLICATION THEREOF | 2019 |
|
RU2751359C2 |
SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AND PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | 2020 |
|
RU2824583C2 |
BIOCHIP INCLUDING SEQUENCING PRIMER AND NON-SEQUENCING UNIT | 2017 |
|
RU2765075C2 |
HEAT-REVERSIBLE BITUMEN COMPOSITION | 2019 |
|
RU2799545C2 |
COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE AND REMOVAL OF PROTECTION FOR SURFACE-BOUND OLIGONUCLEOTIDES | 2019 |
|
RU2766688C2 |
Authors
Dates
2019-08-06—Published
2016-09-26—Filed