POLYMETHINE COMPOUNDS AND USE THEREOF AS FLUORESCENT LABELS Russian patent published in 2019 - IPC C07D403/06 C07D209/08 C09B23/06 C09B23/10 G01N33/00 G01N33/533 

Abstract RU 2696562 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound of formula (I) or mesomer thereof:

,

where mCat+ or mAn- is an organic or inorganic positive/negatively charged counterion, and m is integer from 0 to 2; p is integer from 1 to 2; q is integer from 1 to 5; alk is a carbon chain containing 1 to 5 carbon atoms; Y is O or CH2; Z is OH; n is 0 or 1; X is OH or O-; Ra1 is SO3- or additional C6-cycle condensed with adjacent carbon atom, where additional cycle contains SO3-; Ra2 is H; Rc1 is C1-C6 alkyl; Rc2 is C1-C6 alkyl or group C1-C6 alkylsulphonic acid. Invention also discloses use of a compound of formula (I) for labelling a nucleotide or an oligonucleotide and using a nucleotide.

EFFECT: disclosed compounds can be used as fluorescent labels for nucleotides used in sequencing nucleic acids.

21 cl, 5 dwg, 2 tbl

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RU 2 696 562 C1

Authors

Franse Antuan

Lyu Syaokhaj

Dates

2019-08-06Published

2016-09-26Filed