COUMARINS SUBSTITUTED WITH SECONDARY AMINES AND THEIR USE AS FLUORESCENT LABELS Russian patent published in 2021 - IPC C07D405/04 C07D413/04 C07D417/04 C07F9/44 C12Q1/68 

Abstract RU 2756272 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of the Formula (I) or to its salt, where X is O, S or NRn, where Rn is H; each of R and R1 is independently H; each of R2 and R4 is independently H or -SO3H; R3 is C2-6alkyl substituted with -CO2H; each R5 is independently halogen or -SO3H; and m is 0 or 1. The invention also relates to a nucleotide or oligonucleotide labeled with the specified compound.

EFFECT: technical result is that new compounds are obtained that can be used as fluorescent labels for nucleotides in the sequencing of nucleic acids.

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22 cl, 3 dwg, 2 tbl, 5 ex

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RU 2 756 272 C2

Authors

Romanov, Nikolaj Nikolaevich

Makkoli, Patrik

Enestejsi, Kerol

U, Syaolin

Khajns, Najll

Dates

2021-09-29Published

2018-10-16Filed