CYCLIC AMINE DERIVATIVE AND ITS MEDICAL APPLICATION Russian patent published in 2019 - IPC C07D211/36 C07D211/38 C07D211/44 C07D211/96 C07D401/06 C07D405/06 C07D413/06 A61K31/445 A61K31/454 A61P17/06 A61P25/00 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a cyclic amine derivative of formula (I)

,

where R¹ is an alkoxy group having 1–3 carbon atoms, any 1–3 hydrogen atoms of which are optionally replaced with a halogen atom(s); R² is a halogen atom; R³ represents a hydrogen atom, a halogen atom or a hydroxy group; R⁴ is a hydrogen atom or a halogen atom; X is -C(=O)-(CH₂)_n-R⁵ or -S(=O)₂-R⁶; n is integer from 0 to 5; R⁵ is a hydrogen atom, -OR⁷, -SR⁷, -S(=O)₂-R⁷, -C(=O)-OR⁷, -N(R⁷)R⁸, an alkyl group having 1–3 carbon atoms, any 1–3 hydrogen atoms of which are optionally replaced with a halogen atom(s), or 5-membered ring heteroaryl group containing 1 to 4 heteroatoms independently selected from a group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, any hydrogen atom(s) of which is optionally replaced by an alkyl group(s) having 1–3 carbon atoms; R⁶ is an alkyl group having 1–5 carbon atoms; R⁷ represents a hydrogen atom or an alkyl group having 1–3 carbon atoms, any 1–3 hydrogen atoms of which are optionally replaced with a halogen atom(s); and R⁸ represents a hydrogen atom, an alkyl group having 1–3 carbon atoms, an acyl group having 2–4 carbon atoms, or an alkylsulphonyl group having 1–3 carbon atoms, or a pharmaceutically acceptable salt thereof.

EFFECT: disclosed is a cyclic amine derivative which has retinoid orthophanic receptor antagonist activity γ and has a therapeutic effect or preventive effect on autoimmune diseases.

11 cl, 12 dwg, 3 tbl, 74 ex