METHOD FOR PHOTODYNAMIC THERAPY OF SKIN CANCER Russian patent published in 2019 - IPC A61K31/409 A61P35/00 A61K51/00 

FIELD: medicine.

SUBSTANCE: claimed invention refers to medicine and represents a method of photodynamic therapy of skin cancer. Within the declared method, a photodynamic therapy of skin cancer is suggested to be a photosensitizer of one chemical structure possessing low dark toxicity, namely, coproporphyrin. Photosensitiser is first introduced intravenously in form of 0.4 % coproporphyrinsolution to achieve vascular phototoxic action during irradiation, then applied superficially in form of 5 % ointment to achieve cytotoxic action during irradiation, followed by irradiation of the tumour with wavelength 635 ± 5 nm and radiation dose 300 ± 10 J/cm². PDT is performed not earlier than 3 hours and not later than 24 hours after intravenous administration and surface application of coproporphyrin. For complete elimination of the tumour, a repeated PDT session is performed at any moment in the absence of contraindications on the skin side. Disclosed method eliminates disadvantages of known analogues and a prototype, such as use of different photosensitizers with unexplored interaction, long-term waiting for PDT procedure and impossibility of performing the repeated PDT procedure in a short period of time.

EFFECT: combined use of the disclosed method enables efficient removal of malignant growths.

4 cl, 1 ex, 3 tbl, 2 dwg