1,3,4-OXADIAZOLE HOMOPHTHALIMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Russian patent published in 2023 - IPC C07D413/06 C07D413/10 C07D413/14 C07D487/08 C07D491/107 A61K31/4245 A61K31/4439 A61K31/4725 A61K31/506 A61K31/517 A61P1/00 A61P3/00 A61P5/00 A61P17/00 A61P19/00 A61P25/00 A61P27/02 A61P31/00 

FIELD: pharmaceutical chemistry.

SUBSTANCE: group of inventions relates to pharmaceutical chemistry and includes a compound with formula (I), (II), specific compounds indicated in the claims, their use, as well as a pharmaceutical composition and an inhibition method based thereon. In formula (I) X₁ - X₄ independently refer to CR₀ or N, where at least two of X₁ - X₄ are CR₀, R₀ is independently H or halogen, R₁ is linear or branched -C₁-₅ haloalkyl, R₂ and R₃ are all independently H, halogen, , 3-7-membered heterocycloalkyl containing from 1 to 3 heteroatoms selected from the group including N, O or S, 3-7-membered heterocycloalkenyl containing from 1 to 3 heteroatoms selected from the group including N, O or S , 5- or 6-membered heteroaryl containing from 1 to 3 heteroatoms selected from the group consisting of N, O or S, , , , , , phenyl, indolyl or , K is O or S, Y is CR_a R_b, NR_c or a single bond, R_a and R_b are all independently hydrogen or -C _1-7 alkyl or R_a and R_b are bonded to each other and form a 3- 7-membered cycloalkyl, ring A is phenylene, n is 0 or 1, other substituents are as defined in the claims. In formula (II), X₁ - X₄ are independently CR ₀ or N, where at least two of X₁ - X₄ are CR ₀, where R₀ is H, R ₁ is linear or branched -C _1-5 haloalkyl , R₂ and R₃ are all independently H, K is O, Y is NR_c, R_c is -C_1-7 alkylphenyl, -C_1-7 alkylheteroaryl, in which case heteroaryl is 5- or 6-membered heteroaryl , containing from 1 to 3 heteroatoms selected from the group consisting of N, O or S, or -C _1-7 alkyl-OC _1-7 alkyl, where one H atom of the group is -C_1-7 alkylheteroaryl, in this case heteroaryl is a 5- or 6-membered heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of N, O or S, may be substituted by the following substituent: heteroaryl-C_1-5 haloalkyl, in which case heteroaryl is 5- or 6-membered heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of N, O or S, ring A is phenylene, n is 0 or 1.

EFFECT: 1,3,4-oxadiazole derivatives having the properties of a highly selective HDAC6 inhibitor.

12 cl, 2 tbl, 1 ex