DISCLOSED ARE 1,3,4-OXADIAZOLE THIOCARBONYL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEM Russian patent published in 2024 - IPC C07D271/10 C07D413/12 C07D413/14 A61K31/496 A61K31/5377 A61K31/541 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to 1,3,4-oxadiazole thiocarbonyl compounds of formula I, where each L₁, L₂ and L₃ independently represents a single bond or -(C₁-C₄ alkylene)-; R₁ is -(C₆-C₁₂ aryl), in R₁, at least one H -(C₆-C₁₂ aryl) can be independently substituted with -T; R₂ is structure (a), where each a and b independently represent integer 2 and Y₁ is O or NR^F, and Y₅ is N, structure (b), where a=b=c=d=1, when Y₂ is NR^F and Y₆ is N, or a=b=1 and c=d=2, when Y₆=CH and Y₂=NR^F, or structure (c), where f=1 and Y₇ is NR^F; R₃ is -CT₂H; each Z₁-Z₄ is independently CR^Z; R^Z is -H or T; R^F is -H, - (C₁-C₆ alkyl), -C(=O)-(C₁-C₄ alkyl), or -(C₂-C₆ heterocycloalkyl) containing 1 heteroatom O; fragment (d) is a single bond; and each T is F or Cl. Invention also relates to a pharmaceutical composition based on a compound of formula I or pharmaceutically acceptable salts thereof, a method of inhibiting HDAC6 by administering a compound of formula I or pharmaceutically acceptable salts thereof and the use of the compound of formula I or pharmaceutically acceptable salts thereof in the preparation of a drug for inhibiting HDAC6.

EFFECT: obtaining compounds of formula I, having inhibitory activity on histone deacetylase 6 (HDAC6).

10 cl, 2 tbl, 47 ex