HUMANISED ANIMALS BY C5 AND C3 Russian patent published in 2020 - IPC A01K67/27 A61K49/00 C12N15/85 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of biochemistry, in particular to a rodent for expression of a modified gene C3, the genome of which comprises replacement of a sequence of a rodent gene C3 in an endogenous locus C3 of a rodent by a sequence of a human C3 gene to form a modified gene C3, as well as a method for production thereof, an embryo and a cell thereof. Also disclosed is rodent for expression of modified gene C3 and modified gene C5. Above rodent genome comprises replacement of the C5 rodent gene sequence by a human C5 gene sequence to form a modified C5 gene and replacing the rodent gene C3 sequence in the rodent endogenous locus C3 by the human C3 gene sequence to form a modified C3 gene. Invention also relates to a method for identifying a compound capable of modulating activation of a complement system involving use of said rodent.

EFFECT: invention enables efficient identification of a compound capable of modulating activation of a complement system.

26 cl, 12 dwg, 1 tbl, 6 ex