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(19)

(11)

2 701 662

(13)

(51)

IPC

C12N15/113(2010-01-01)

C12N15/79(2006-01-01)

C12N15/90(2006-01-01)

A61K48/00(2006-01-01)

C12N9/22(2006-01-01)

(21) (22)

Application

2015128102, 2013-12-12

(24)

Start date

2013-12-12

(22)

Actual filing date

2013-12-12

(45)

Published

2019-09-30

(72)

Inventor

Chzhan FenBikard Devid OliveTsun LeKoks Devid Bendzhamin TuritsKhsyu PatrikTszyan VenyanLin ShaujlyanMarraffini LuchanoPlatt Rendol DzheffriZhan FejSandzhana Nevill Espi

(73)

Holder

Te Brod Instityut, Ink.Massachusets Instityut Of TeknolodzhiPrezident End Fellouz Of Kharvard KollidzhTe Rokfeller Yuniversiti

CRISPR-CAS SYSTEM COMPONENTS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION Russian patent published in 2019 - IPC C12N15/113 C12N15/79 C12N15/90 A61K48/00 C12N9/22

Abstract RU 2701662 C2

FIELD: biotechnology.

SUBSTANCE: present invention refers to biotechnology. Disclosed are compositions and systems containing vectors comprising polynucleotide sequences coding components of CRISPR-Cas type II complex, as well as a kit containing one of such compositions or systems.

EFFECT: present invention enables the change of genomic loci of the eukaryotic cell by using Cas9 nuclease fused with one or more nuclear localization sequences (NLS).

25 cl, 74 dwg, 16 ex

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RU 2 701 662 C2

Authors

Chzhan Fen

Bikard Devid Olive

Tsun Le

Koks Devid Bendzhamin Turits

Khsyu Patrik

Tszyan Venyan

Lin Shaujlyan

Marraffini Luchano

Platt Rendol Dzheffri

Zhan Fej

Sandzhana Nevill Espi

Dates

2019-09-30—Published

2013-12-12—Filed