METHOD OF PRODUCING 2,3-DIALKYL-N-PHENYL-1,2,3,4-TETRAHYDROQUINOLINE-4-AMINES Russian patent published in 2019 - IPC C07D215/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 2,3-dialkyl-N-phenyl-1,2,3,4-tetrahydroquinoline-4-amines by reacting aniline with aldehydes in the presence of a catalyst, characterized in that the catalyst used is zeolite Y in H form, reaction of aniline with aliphatic aldehyde (propionic, butyric or valeric) is carried out in a flow reactor with a fixed catalyst bed at 250–350 °C, raw material feed rate volume of 2–10 h^-1, at atmospheric pressure, nitrogen flow and molar ratio aniline : aldehyde 1:2.

EFFECT: novel simplified method of producing 2,3-dialkyl-N-phenyl-1,2,3,4-tetrahydroquinoline-4-amines, which enables to reduce energy and material consumption of the heterocyclisation process.

1 cl, 1 tbl, 3 ex