METHOD FOR ASSESSING OF SCAFFOLDS BIOCOMPATIBILITY Russian patent published in 2020 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, biology, veterinary science, pharmacology. Scaffold is implanted in the form of disc under the skin of rats. 7 days after the implantation, blood is sampled under general anesthesia. Blood is centrifuged to produce serum wherein concentration of Vascular Endothelium Growth Factor-A (VEGF) and syndecan-1 is determined. Obtained concentration ratio is calculated. For normalization of the ratio of concentrations of VEGF and syndecan-1, it is multiplied by a correction factor K, defined as the ratio of median values of syndecan-1 and VEGF concentrations in intact animals. If the normalized value of the ratio of the concentrations of VEGF and syndecan-1 does not exceed 2, then the absence of biocompatibility in the scaffold is stated.

EFFECT: method enables reducing the time span of quantitative assessment of scaffold's biocompatibility with body tissues, as well as reducing labor intensity when assessing vascularization of biodegradable scaffolds.

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