METHOD FOR NON-INVASIVE MONITORING OF A FLUORESCENT INDICATOR AGENT WITH A LABELED ATOM WITH BACKGROUND SEPARATION CORRECTIONS Russian patent published in 2020 - IPC A61B5/00 G01N21/64 

FIELD: medicine.

SUBSTANCE: invention refers to medical diagnostics and concerns a method for monitoring of time varying fluorescence emitted from a fluorescent agent from inside a diffuse reflecting medium with variable optical properties in time. Method involves obtaining at least two measurements received from a patient before and after administration of the fluorescent agent. Measurements contain a fluorescence signal detected during illumination of the diffuse reflecting medium by radiation with excitation wavelength, and at least one diffuse reflection signal. Each fluorescence signal of each record of measurement data in the part of the set of measurement data obtained after achieving equilibrium is converted into a signal which is the intensity of fluorescence emitted only by means of a fluorescent agent from inside the diffusion reflecting medium. Conversion includes removal of effects of through passage of excitation level radiation and removal of autofluorescence effects.

EFFECT: technical result is higher accuracy and repeatability of measurements.

12 cl, 32 dwg, 2 tbl