METHOD OF SYNTHESIS OF AROMATIC OXIMES Russian patent published in 2020 - IPC C07D233/34 

FIELD: chemical or physical processes.

SUBSTANCE: invention relates to synthetic synthesis of compound of formula (I), which includes two successive steps (b1) and (b2) in accordance with principles of single-reactor synthesis. Step (b1) comprises reacting a compound of formula (II) with a compound of formula Z-Sp-A (III) in the presence of at least one polar solvent, at least one base at temperature T₁ from 70 to 150 °C in order to form ether. At step (b2), said ether is reacted with aqueous hydroxylamine solution at temperature T₂ from 30 to 70 °C. In said formulas, A is a binding group, selected from a group of imidazolidinyl, thioimidazolidinyl, triazoyl, trithioazoyl, ureyl, thioureyl, bis-ureyl, bis-thioureyl, ureidopyrimidyl and thioureidopyrimidyl or a group corresponding to formula (IV): -C(OR₂)=O (IV), where R₂ is a carbon group containing 1 to 20 carbon atoms and optionally containing at least one heteroatom; R¹ is C₁-C₁₂ alkyl group or OR', where R' is C₁-C₁₂ alkyl group; n is integer from 0 to 4; Sp is a linear or branched C₁-C₂₄ alkylene chain optionally interrupted by one or more nitrogen or oxygen atoms; Z—nucleofug.

(I)

(II).

EFFECT: disclosed method reduces the number of steps without detriment to purity of target oximes and without reducing their output.

23 cl, 3 ex