FIELD: biotechnology.
SUBSTANCE: invention refers to biotechnology, namely to techniques for searching for new therapeutic preparations or combinations of preparations (chemical compounds) which improve existing therapeutic approaches to treating cancer. Disclosed is a test system, to which the analyzed preparation (test substance) is added, and then the number of translocations formed compared to the control is concluded on the risk of secondary leukemia. Disclosed is a test system which enables to study the effect of different substances on the frequency of formation of rearrangements between loci AML and ETO, and hence their effect on the probability of secondary leukemia.
EFFECT: disclosed are a test system for searching for drugs which reduce the risk of secondary leukemia, a method for preparing and using it.
18 cl, 12 dwg, 6 tbl, 1 ex
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