METHOD FOR PREDICTION OF DEVELOPMENT OF COGNITIVE DISORDERS IN PATIENTS IN EARLY RECOVERY OF ISCHEMIC STROKE Russian patent published in 2020 - IPC A61B5/16 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to neurology, and can be used for prediction of development of cognitive disorders in early recovery period of ischemic stroke (on 87–90 days) according to clinical-laboratory-instrumental criteria, obtained in acute period of disease (1–3 days). For prediction calculation data of one complex examination of patient are required. During neuropsychological testing, a short score on the assessment of mental status (X1) is determined; score by battery tests for assessing frontal dysfunction (X2); by clock drawing test (X3). According to computer tomograms performed when entering hospital, there is an analysis of the presence of lacunar ischemic lesions not associated with the present disease (X4), which is assessed in points by rank method (0 - no lesions, 1 - single foci; 2 - presence of 3 to 5 lacunar foci; 3 - more than 5 foci). Blood serum concentration of matrix metalloproteinase-9 in ng/ml (X5) is determined in blood for 1 day of ischemic stroke by enzyme immunoassay. Further, linear-discriminant functions (LDF) are calculated using the formulas. If LDF1 > LDF2 > LDF3, normal level of cognitive functions is expected in the patients. If LDF2 > LDF1 > LDF3, moderate mild cognitive impairment is expected in the patients. In LDF3 > LDF1 > LDF2, the patients are expected to develop severe cognitive disorders.

EFFECT: prognostic model enables simple, highly sensitive and specific prognosis of development of cognitive disorders in early recovery period of ischemic stroke ensured by complex assessment of neuropsychological, laboratory and neuroimaging data.

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