METHOD FOR PREDICTING PROGRESSION OF VASCULAR MODERATE COGNITIVE IMPAIRMENT Russian patent published in 2024 - IPC G01N33/68 G01N33/86 G01N33/573 A61B5/18 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neurology, and can be used to predict progression of vascular moderate cognitive impairment (MCI). Determination of demographic, clinical-anamnestic and laboratory data is carried out. Blood levels of endothelial inflammation markers – C-reactive protein (x₂₃) in mg/ml and biomarkers of endothelial dysfunction – endothelial NO-synthase (x₂₆) in pg/ml, fibrinogen (x₃₁) in g/l are determined. In addition, neuropsychological testing according to the Montreal scale for assessing cognitive functions involves evaluating an index of executive functions (x₁₇) and a speech index (x₁₉) in points. Patient’s age (x₂), number of complete years are determined. Information on suffered stroke (x₁₁), reduced to ordinal/binary form, is assessed: 1 – yes, 0 – no. Risk values are calculated by linear discriminant equation: Risk=1/(1+e^{-(-52.64-0.45392×X2-2.652002×X11+(-1.2169202)×X17+(-0.853907)×X19+2.5842602×X23+0.66313×X26+1.2361×X31)}). If Risk is more than or equal to 0.4, a high probability of vascular MCI progression is predicted in 12 weeks. If Risk is less than 0.4, a low probability of vascular MCI progression is predicted.

EFFECT: method enables individual prediction of the progression of vascular MCI by increasing the accuracy of estimating the MCI of vascular genesis based on demographic, clinical-anamnestic and laboratory data by including them in a prognostic model.

1 cl, 1 dwg, 7 tbl, 2 ex