FIELD: chemistry.
SUBSTANCE: invention refers to organic chemistry and pharmacology. Disclosed are novel biologically active individual compounds of pyrazolo[1,2-a]pyrrolo[2,3-c]pyrazoles, specifically methyl 2,3,8-trioxo-4-phenyltetrahydro-6H-pyrazolo[1,2-a]pyrrolo[2,3-c]pyrazol-9a(1H)-carboxylates, which are obtained by reacting 1H-pyrrole-2,3-dione (I) with azomethine imine (II) in ratio of 1:1 in a solvent medium at room temperature, followed by separation of desired products. Solvent used is absolute chloroform or other inert aprotic solvents.
EFFECT: compounds have pronounced analgesic activity and can be used as initial products for synthesis of heterocyclic systems and in pharmacology as potential drug preparations with analgesic properties.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| USE OF DIMETHYL (3AR*,4R*,9AS*)-4-(4-METHOXYPHENYL)-2,3,8-TRIOXO-1-PHENYLTETRAHYDRO-6H-PYRAZOLO[1,2-a]PYRROLO[2,3-c]PYRAZOLE-3A,9A(1H,4H)-DICARBOXYLATE AS AGENT WITH ANTIOXIDANT ACTIVITY |
2023 |
- Dmitriev Maksim Viktorovich
- Maslivets Andrei Nikolaevich
- Moroz Anna Andreevna
|
RU2810210C1 |
| ETHYL 5-ALKYL-7,7-DIMETHYL-2',9,11-TRIOXO-5'-PHENYL-1',2',5,6,7,8,9,11-OCTAHYDROSPIRO{INDENO[1,2-b][QUIOLINE-10,3'-PYRROL}-4'-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Dmitriev Maksim Viktorovich
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2485120C1 |
| METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Maslivets Andrej Nikolaevich
- Bubnov Nikolaj Vladimirovich
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Makhmudov Ramiz Ragibovich
|
RU2495039C1 |
| 1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2502738C2 |
| 2-(6-ARYL-4-AROYL-3-METHYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDIN-5-YL)-2-OXO-N-ARYLACETAMIDES AND METHODS FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2501800C2 |
| METHYL 4-ARYL-1-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-2,3-DIOXO-2,3,5,10 -TETRAHYDROBENZO[b]PYRROLO[2,3-e][1,4]DIAZEPINE-10a(1H)-CARBOXYLATES EXHIBITING ANALGESIC ACTIVITY, AND METHOD OF THEIR PREPARATION |
2022 |
- Denislamova Ekaterina Sergeevna
- Liadov Vadim Aleksandrovich
- Makrushin Dmitrii Evgenevich
- Maslivets Andrei Nikolaevich
- Malysheva Kseniia Olegovna
- Triandafilova Galina Andreevna
- Solodnikov Sergei Iurevich
|
RU2811413C1 |
| ETHYL 3',7-DIOXO-5'-PHENYL-1,6-DIHYDRO-1'H-SPIRO{INDENO[1,2-b]QUINOLINE-6,3'-PYRROLE}-4'-CARBOXYLATES AND SYNTHESIS METHOD THEREOF |
2010 |
- Dmitriev Maksim Viktorovich
- Makhmudov Ramiz Ragibovich
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
|
RU2453549C1 |
| (Z)-1'-R-6',6'-DIMETHYL-3-(PHENYL(ARYLAMINO)METHYLENE)-6',7'-DIHYDRO-3H-SPIRO[FURANE-2,3'-INDOL]-2',4,4',5(1'H,5'H)TETRAONS AND METHOD OF THEIR OBTAINING |
2008 |
- Maslivets Andrej Nikolaevich
- Silajchev Pavel Sergeevich
- Aliev Zajnutdin Gasanovich
|
RU2365592C1 |
| METHYL 5-(ARYLCARBAMOYL) -1-(BENZYL AND PHENYL)-4-CINNAMOYL-1H-PYRAZOLE-3-CARBOXYLATES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF |
2014 |
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2583158C2 |
| 1,1'-DIARYL-3'-AROYL-4'-HYDROXY-1H-SPIRO [INDENO[1,2-b]PYRROL-3,2'-PYRROL]-2,4,5'-(1'H)-TRIONES AND METHOD OF THEIR OBTAINING |
2011 |
- Bubnov Nikolaj Vladimirovich
- Denislamova Ekaterina Sergeevna
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2467011C1 |
